Genetic markers of predisposition to athletic performance in Kazakhstani combat athletes: Results of a GWAS study

Madina B. Baurzhan (), Aibol T. Kulbayev (), Alina V. Ten (), Leyla B. Djansugurova () and Nazym K. Altynova ()

International Journal of Innovative Research and Scientific Studies, 2025, vol. 8, issue 6, 2022-2029

Abstract: This study investigated genetic markers associated with athletic performance in Kazakhstani combat sport athletes and assessed their potential role in developing a genetic passport for personalized training. A total of 235 elite wrestlers and boxers and 172 controls were enrolled. DNA was extracted from blood and genotyped using the Illumina iScan platform (654,027 SNPs). Genome-wide association analysis was performed in PLINK, and significant variants were annotated using genomic databases. No genome-wide significant associations (p < 5 × 10⁻⁸) were observed, but several SNPs reached suggestive significance (p < 5 × 10⁻⁶). Variants in CDH13, LIMD1, and ZNF215 were most notable. The CDH13 rs79764367 G allele was enriched in wrestlers, while the A allele was associated with boxing. LIMD1 rs77194734 showed allele-specific differences between wrestling and boxing. ZNF215 rs76704889 was linked to elite-level traits in both groups. This pilot GWAS provides the first evidence of candidate genetic markers in Kazakhstani combat athletes, highlighting allele-specific differences across sports disciplines.

Keywords: CDH13; Combat sports; GWAS; LIMD1; SNP; ZNF215. (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:aac:ijirss:v:8:y:2025:i:6:p:2022-2029:id:10073

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