Synthesis and In Silico Analysis of Chalcone Derivatives as Potential Prostaglandin Synthetase Inhibitors

Samuel J Bunu, Oyeintonbara Miediegha, Ebisindor V Awala, Deghinmotei Alfred-Ugbenbo, Baba Haruna and Cyril O Usifoh
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Samuel J Bunu: Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Nigeria
Oyeintonbara Miediegha: Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Nigeria
Ebisindor V Awala: Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Nigeria
Deghinmotei Alfred-Ugbenbo: Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Bayelsa Medical University, Nigeria
Baba Haruna: Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Calabar, Nigeria
Cyril O Usifoh: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Nigeria

Biomedical Journal of Scientific & Technical Research, 2024, vol. 55, issue 2, 46709-46720

Abstract: Nine derivatives of chalcones were successfully synthesized using the Claisen- Schmidt condensation reaction between different derivatives of benzaldehyde and acetophenone at low temperature in the presence of potassium hydroxide (KOH) and ethanol. The compounds were obtained in high yield. The percentage yield ranges from 90.38 – 27.68%, with sample B having the highest yield while sample I gave lowest yield. Also, the infra-red and nuclear magnetic resonance (FTIR and NMR) spectroscopic analysis shows distinct spectrum across all molecules, indicating the presence of unique functional groups and chemical environments.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:55:y:2024:i:2:p:46709-46720

DOI: 10.26717/BJSTR.2024.55.008662

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