Susceptibility MRI in Brain Nuclei Improves Early Diagnosis of Parkinson’s Disease Using Linear Discriminant Analysis Method

Jian Zhang Xia, Hai Mei Huang, Ya Bin Jin, Yun Jie Rong, Wen Xiu Wu, Ming Yong Gao, Hai Mei Huang and Zhi Feng Xu
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Hai Mei Huang: Department of Radiology, Fifth People’s Hospital of NanHai District, China
Ya Bin Jin: Department of Clinical Research Institute, First People’s Hospital of Foshan, China
Yun Jie Rong: Department of Radiology, Second Affiliated Hospital of Shantou University Medical College, China
Zhi Feng Xu: Department of Radiology, First People’s Hospital of Foshan, China

Biomedical Journal of Scientific & Technical Research, 2024, vol. 55, issue 4, 47249-47257

Abstract: The study aimed to explore a new imaging biomarker based on quantitative susceptibility mapping (QSM) using linear discriminant analysis (LDA) method for improving early diagnosis of Parkinson’s disease. 34 PD patients and 15 controls were enrolled, and the PD patients were divided into two groups (early-stage and advanced-stage groups) based on the Hoehn-Yahr assessment. Magnetic susceptibilities in six brain structures, including the caudate nucleus (CN), globus pallidus (GP), thalamus (THA), putamen (PUT), substantia nigra (SN) and red nucleus (RN), were measured. Mean susceptibilities were measured and compared between the PD patients and controls.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:55:y:2024:i:4:p:47249-47257

DOI: 10.26717/BJSTR.2024.55.008740

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