Therapeutic Effects of Kv7 Channel Activator Retigabine against Seizures and Neurodegeneration in Kainic Acid-Induced Seizure Model

Xiao-fei Zhuang

International Journal of Sciences, 2022, vol. 11, issue 07, 9-14

Abstract: Aims: The current study evaluates whether Kv7 channel activator retigabine (RTG) could attenuate seizures and hippocampal neurodegeneration in the kainic acid (KA) induced seizure model. Methods: The anticonvulsant activity of RTG is evaluated by electroencephalography (EEG) recordings in KA-kindled rats. Tunel assay and immunofluorescence of NeuN are used to evaluate the neuroprotective effect of RTG in the hippocampus of KA-kindled rats. Results: RTG effectively reduces epileptiform discharges induced by KA injection. Tunel assay and immunofluorescence of NeuN show that RTG exerts neuroprotection in the hippocampus of KA-kindled rats. Conclusion: Taken together, this study demonstrates that RTG effectively alleviates seizures and hippocampal neurodegeneration in the KA-induced seizure model.

Keywords: Kv7 Channel; RTG; Kainic Acid; Neuroprotection; Seizure (search for similar items in EconPapers)
Date: 2022
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DOI: 10.18483/ijSci.2598

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