Effect of Stereotactic Hematoma Aspiration on the NSE Expression after Experimental Intracerebral Hemorrhage

Yanan Wang, Zhaoxing Li, Chengjie Sun, Xiaoying Wang, Kai Luo, Hongyan Zhang, Ning Gu and Dehui Zhu

International Journal of Sciences, 2015, vol. 4, issue 08, 58-67

Abstract: Objective: To observe the effect of stereotactic hematoma aspiration on the expression of neuron-specific enolase (NSE) in perihematomal tissue after intracerebral hemorrhage. Methods: The model of intracerebral hemorrhage were established by using inracerebral stereotaxic injection of type IV collagenase method in male adult Wistar rats and were randomly divided into sham operation group, intracerebral hemorrhage group, and hemorrhage aspiration group. The neurological impairment in rats were evaluated by means of Bederson four grade. The morphology of nerve cells in cortex were observed by the hematoxylin-eosin staining. The expression of NSE in cortex was detected respectively by the immunohistochemistry and Western Blot. Results: The expression of NSE in the peripheral region of hematoma in hematoma aspiration group and intracerebral hemorrhge group was significantly higher than that in sham operation group each time point after intracerebral hemorrhage (P

Keywords: NSE; Intracerebral Hemorrhage; Stereotactic Hematoma Aspiration; Rat (search for similar items in EconPapers)
Date: 2015
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DOI: 10.18483/ijSci.795

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