Expression and Significance of GRP78 and HER-2 in Colorectal Cancer

Xiaoming Xing, Qiu-xia Ji, Li-li Wang and Lin Li

International Journal of Sciences, 2016, vol. 5, issue 04, 59-63

Abstract: Background and objective GRP78 and HER-2 expression are related to disease behaviors in various cancers. Previous research has shown that GRP78 is overexpressed in colorectal cancer and plays an important role in the development and progression of colorectal cancer. And evidence for HER-2 expression in colorectalcancer is contradictory for the protein expression status and prognostic value. In our study, we aim to investigate GRP78 and HER-2 expression in colorectal cancer and explore their association with clinicopathological features. Methods Immnunohistochemical staining was used to assess the expression of GRP78 and HER-2 in 117 cases of colorectal carcinoma and corresponding adjacent tissues were selected for comparative analysis. Results The positiverate of GRP78 and HER-2 were 68.4% (80/117) and 38.5% (45/117) respectively. The expression of GRP78 and HER-2 in gender, age, tumor size, tumor position, histological grade, depth of invasion and lymph node metastasis had no significant difference (all P > 0.05); No relationship between GRP78 and HER-2 expression was detected ( P = 0.089). Conclusion GRP78 and HER-2 were not predictors for development and progression in CRC patients. The results do not support any relationship between GRP78 and HER-2 expression in this setting.

Keywords: GRP78; HER-2; Colorectal cancer; Immunohistochemistry (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.ijsciences.com/pub/article/1001 (text/html)
https://www.ijsciences.com/pub/pdf/V52016041001.pdf (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adm:journl:v:5:y:2016:i:4:p:59-63

Ordering information: This journal article can be ordered from
https://www.ijsciences.com/payment_guide.php

DOI: 10.18483/ijSci.1001

Access Statistics for this article

More articles in International Journal of Sciences from Office ijSciences Alkhaer Publications Manchester M8 8XG England.
Bibliographic data for series maintained by Staff ijSciences ().