Study on the Expression of PCNA in Hypertrophic Scar Cell Model

Rong’an Hao, Yu An and Kun Yuan

International Journal of Sciences, 2018, vol. 7, issue 11, 44-47

Abstract: Objective Study the expression of PCNA under different mechanical tension on the transformation of normal skin fibroblasts (NSFB) to hypertrophic scar fibroblasts(HSFB). Methods NSFB and HSFB were divided into the stretch group and the control group. Stretch groups were loaded with 0.1Hz, 10% amplitude cyclic stretch for 3, 5 and 7 days respectively. Control group were cultured without cyclic stretch. At the end of experiments, cell proliferation was determined by CCK8, immunocytochemistry（ICC）of proliferating cell nuclear antigen (PCNA). Results When loaded for 5 days with amplitude cyclic stretch, compared with HSFB control group, expression levels of PCNA of the NSFB stretch group were no significant differences (P>0.05); while loaded for 3 days or 7 days, the above indexes showed significant differences (P

Date: 2018
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DOI: 10.18483/ijSci.1844

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