Regulation of Feeding and Mechanisms of Intracerebroventricular Injection of Nesfatin-1 in Obese Rats

Xue Ruimei, Wang Mi, Leng Hui, Sun Xiangrong and Xu Luo

International Journal of Sciences, 2018, vol. 7, issue 04, 64-70

Abstract: Objective: Aim to discuss the effects of intracerebroventricular injection of nesfatin-1 on the feeding of normal rats and obese rats to clarify the mechanism of feeding regulation. Methods: Using the BioDAQ feeding monitoring system to monitor 24h food intake, bout size, meal size, bout frequency, meal frequency, meal interval and meal duration of rats. Results: Intracerebroventricular injection of nesfatin-1 reduced the amount of 24h food intake in normal rats, food intake at fifth hour significantly reduced; After intracerebroventricular injection of nesfatin-1 in normal rats, meal size, meal duration and the percentage of time spent eating significantly reduced, meal interval and meal frequency did not change significantly, satiety ratio significantly increased; Intracerebroventricular injection of nesfatin-1 reduced the amount of 20h food intake in obese rats, food intake at third hour significantly reduced; Intracerebroventricular injection of nesfatin-1 significantly reduced bout frequency, meal frequency and eating rate in obese rats, with a significant increase in meal interval and satiety ratio. Conclusion: Nesfatin-1 can inhibit the feeding of normal rats and obese rats. The normal rats showed increased satiation, the obese rats showed increased satiety, and the nesfatin-1 can regulate the feeding of normal rats and obese rats via different pathway.

Keywords: Food intake; Nesfatin-1; Obesity (search for similar items in EconPapers)
Date: 2018
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DOI: 10.18483/ijSci.1631

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