Optimizing Tests about Survival Probabilities in the One-Arm Phase II Cancer Clinical Trial Setting

Alan D Hutson and William E Brady
Additional contact information
Alan D Hutson: Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, USA
William E Brady: Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, USA

Biostatistics and Biometrics Open Access Journal, 2017, vol. 2, issue 2, 30-37

Abstract: In this note, we examine the effect of the choice of the time point, t, at which to dichotomize time-to-event endpoints in single-arm, phase II, oncology clinical trials. These trials routinely treat these endpoints as binomial random variables, but there has been no examination of the effect of the choice of t on the trial’s design and operating characteristics, including type I error rate control, sample size and power, and total study duration (accrual plus follow-up time).

Keywords: Biometrics Open Access Journal; Biostatistics and Biometrics; Biostatistics and Biometrics Open Access Journal; Open Access Journals; biometrics journal; biometrics articles; biometrics journal reference; biometrics journal impact factor; biometrics and biostatistics journal impact factor; journal of biometrics; open access juniper publishers; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/bboaj/pdf/BBOAJ.MS.ID.555582.pdf (application/pdf)
https://juniperpublishers.com/bboaj/BBOAJ.MS.ID.555582.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jbboaj:v:2:y:2017:i:2:p:30-37

DOI: 10.19080/BBOAJ.2017.02.555582

Access Statistics for this article

Biostatistics and Biometrics Open Access Journal is currently edited by Sophia Mathis

More articles in Biostatistics and Biometrics Open Access Journal from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().