AMP-Activated Protein Kinase: Its Regulation by Different Sites

Katherine M Allen and Asish K Saha
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Katherine M Allen: Department of Medicine, Boston University Medical Center, USA
Asish K Saha: Department of Medicine, Boston University Medical Center, USA

Current Research in Diabetes & Obesity Journal, 2017, vol. 2, issue 5, 88-90

Abstract: Type 2 diabetes (T2D), as well as other metabolic diseases, is an increasing global health concern and many of the mechanisms of both the disease and its current drug treatments have not been fully described. Numerous pharmaco¬logical agents, natural compounds, and hormones are known to activate AMP-activated protein kinase (AMPK), either directly or indirectly-some of which (for example, metformin and thiazolidinediones) are currently used to treat T2D. It has been shown that the anti-diabetic class of drugs, the thiazolidinediones, works via both a known PPAR γ-dependent, and a lesser known PPARγ-independent mechanism of action. This PPAR γ-independent mechanism likely involves the metabolic regulatory molecule AMPK, which has a newly elucidated inhibitory site of phosphorylation at Ser485/Ser491. This paper will review the regulation of the AMPK pathway by both its activation and inhibitory sites and the potential for future improvements in targeting AMPK for the treatment of T2D.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:2:y:2017:i:5:p:88-90

DOI: 10.19080/CRDOJ.2017.02.555597

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