Bariatric Surgery for the Treatment of Diabetic Kidney Disease

William P Martin, Neil G Docherty and Carel W Le Roux
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William P Martin: Department of Medicine, Galway University Hospitals, Saolta University Healthcare Group, Galway, Ireland
Neil G Docherty: Department of Medicine, Galway University Hospitals, Saolta University Healthcare Group, Galway, Ireland
Carel W Le Roux: Department of Medicine, Galway University Hospitals, Saolta University Healthcare Group, Galway, IrelandAuthor-Workplace-Name: Department of Gastrosurgical Research and Education, University of Gothenburg, Sweden

Current Research in Diabetes & Obesity Journal, 2017, vol. 3, issue 5, 90-93

Abstract: Diabetic kidney disease is increasing in prevalence concordant with the inter-related diabetes and obesity pandemics. The potential mechanisms by which bariatric surgery may improve the course of diabetic kidney disease need to be understood to determine potential usefulness and risks of these interventions. Renal haemodynamics are altered in patients with diabetes and obesity and glomerular hyperfiltration is implicated as an initiating event in the genesis of renal functional decline. Effacement of glomerular podocyte foot processes and consequent albuminuria occur adaptively in response to glomerular hypertension, and when compounded by metabolic deregulation in the form of insulin resistance, hyperglycemia, and dyslipidaemia precipitate renal inflammation and oxidative stress.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:3:y:2017:i:5:p:90-93

DOI: 10.19080/CRDOJ.2017.03.555624

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