Cannabinoids Receptors in Liver: Diet and Physiopathology

Valeska Castillo, Cynthia Barrera, Rodrigo Troncoso, Ana María Ronco and Miguel Llanos
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Valeska Castillo: Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile
Cynthia Barrera: Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile
Rodrigo Troncoso: Laboratorio de Enfermedades Crónicas Asociadas a la Nutrición, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile
Ana María Ronco: Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile
Miguel Llanos: Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Chile

Current Research in Diabetes & Obesity Journal, 2017, vol. 4, issue 1, 11-14

Abstract: The Endocannabinoid system (SEC), located in the central nervous system and several peripheral tissues, is an important modulator of many metabolic functions. This system, is composed by cannabinoid receptors type 1 and 2 (CB1R; CB2R), their endogenous ligands, known as Endocannabinoids, and the enzymes involved in their synthesis and degradation. It has been suggested that a hyperactivated SEC originates metabolic disruptions in several tissues, resulting in typical manifestations of the metabolic syndrome. Liver steatosis due to consumption of a high fat diet is a pathophysiological condition associated to a perturbed SEC. In this condition, it has been shown an increased expression of CB1R and/or higher endocannabinoid levels in hepatic cells, which may exert an autocrine/paracrine stimulation of CB1R and CB2R.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:4:y:2017:i:1:p:11-14

DOI: 10.19080/CRDOJ.2017.04.555628

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