Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice

Luis F Hernandez, Peter Buchwald and Midhat H Abdulreda
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Luis F Hernandez: Diabetes Research Institute, University of Miami Miller School of Medicine, USA
Peter Buchwald: Diabetes Research Institute, University of Miami Miller School of Medicine, USA
Midhat H Abdulreda: Diabetes Research Institute, University of Miami Miller School of Medicine, USA

Current Research in Diabetes & Obesity Journal, 2018, vol. 5, issue 3, 49-55

Abstract: Metabolism of the amino acid L-arginine is implicated in many physiological and pathophysiological processes including autoimmune conditions such as type 1 diabetes (T1D). Alternate arginine metabolism through the citrulline-nitric oxide (NO) or the ornithine pathways can lead to proinflammatory or immune regulatory effects, respectively. In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nω-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2018
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:5:y:2018:i:3:p:49-55

DOI: 10.19080/CRDOJ.2018.05.555661

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