VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families

Natalia Gomez Lopera, Alejandra Rodriguez, Martin Toro, Maria Victoria Lopera, Alejandra Velez, Juan Manuel Alfaro and Nicolas Pineda Trujillo
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Natalia Gomez Lopera: Grupo Mapeo Genético, Departamento de Pediatría, Facultad de Medicina. Universidad de Antioquia, Colombia
Alejandra Rodriguez: Grupo Mapeo Genético, Departamento de Pediatría, Facultad de Medicina. Universidad de Antioquia, Colombia
Martin Toro: Seccion de Endocrinología, Departamento de Pediatria, Universidad de Antioquia, Colombia
Maria Victoria Lopera: Seccion de Endocrinología, Departamento de Pediatria, Universidad de Antioquia, Colombia
Alejandra Velez: Pontificia Universidad Bolivariana, Facultad de Medicina, Colombia
Juan Manuel Alfaro: Grupo Mapeo Genético, Departamento de Pediatría, Facultad de Medicina. Universidad de Antioquia, Colombia
Nicolas Pineda Trujillo: Pontificia Universidad Bolivariana, Facultad de Medicina, Colombia

Current Research in Diabetes & Obesity Journal, 2018, vol. 6, issue 3, 42-48

Abstract: Vitamin D and its receptor are possibly related to T-cell-mediated autoimmune diseases and influences susceptibility to Type 1 diabetes (T1D). The aim of this study was to assess the contribution of vitamin D receptor (VDR) polymorphisms to the susceptibility to T1D in a Colombian sample. Associations of VDR gene variants with T1D were investigated in a sample of 200 familial trios from Colombia. VDR polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236), were determined using PCR-RFLP methodology.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:6:y:2018:i:3:p:42-48

DOI: 10.19080/CRDOJ.2018.06.555688

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