Alpha-Lipoic Acid: Therapeutic Potential in Diabetic Neuropathies

Victoria Serhiyenko, Ludmila Serhiyenko, Mychailo Krasnyi and Alexandr Serhiyenko
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Victoria Serhiyenko: Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine
Ludmila Serhiyenko: Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine
Mychailo Krasnyi: Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine
Alexandr Serhiyenko: Department of Endocrinology, Danylo Galytsky Lviv National Medical University, Ukraine

Current Research in Diabetes & Obesity Journal, 2018, vol. 7, issue 3, 57-61

Abstract: Diabetic neuropathy due to nerve damage caused by uncontrolled hyperglycemia is a common and serious complication strongly associated with diabetes mellitus. Its management focuses on long-term durable glycaemic control, multifactorial cardiovascular risk intervention, pathogenesis-oriented therapy. Clinical trials clearly suggest beneficial effects of α-lipoic acid (ALA) consumption on lipid metabolism profile, endothelial activation, its anti-inflammatory, antithrombotic and antiatherosclerotic properties. We reviewed available evidence of the benefits of ALA administration, especially to patients with diabetic neuropathy, diabetic peripheral neuropathy, diabetic cardiovascular autonomic neuropathy, including effects on glucose and lipids metabolism parameters, thrombocyte aggregation state, endothelial function and antioxidant/anti-inflammation properties.

Keywords: juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jcrdoj:v:7:y:2018:i:3:p:57-61

DOI: 10.19080/CRDOJ.2018.07.555713

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