Present Situation of Viral Vector Manufacturing and Ways to Overcome Potential Barriers in View of the Routine Large Scale Production and Use of Viral Vectors

Merten O-W
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Merten O-W: Généthon, France

Current Trends in Biomedical Engineering & Biosciences, 2017, vol. 7, issue 1, 13-20

Abstract: The marketing authorization of two gene therapy treatments in Europe has opened the door to routine manufacturing of viral vectors, in particular, of MLV, LV, and AAV vectors, meaning that a quantum leap in routine manufacturing technology will be necessary in order to be able to produce the required quantities. However, this quantum leap is already required for producing the vector amounts necessary for performing advanced clinical trials, in particular, with respect to neuromuscular diseases (NMDs), such as Duchene Muscular Dystrophy (DMD). This review presents briefly the actual situation of the production of the most important viral vectors (AV, MLV, LV, and AAV) and barriers to be overcome in view of the large scale manufacturing of these vectors for routine use.

Keywords: juniper publishers group; juniper publishers Biomedical Engineering journals; Biomedical Engineering journals list; medical devices journals; peer reviewed Biomedical Engineering journals; open access Biomedical Engineering journals; Biomedical Engineering journals impact factor; Biomedical Engineering scientific journals; Biomedical Engineering articles; scholarly Biomedical Engineering journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctbeb:v:7:y:2017:i:1:p:13-20

DOI: 10.19080/CTBEB.2017.07.555704

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