Label-Free Screening of Bio-Molecular Interactions Based on Raman Spectroscopy and a Novel Delta Modulation and Similarity-Based Signal Analysis Method

Petra Perner
Additional contact information
Petra Perner: Institute of Computer Vision and Applied Computer Sciences, IBaI, Germany

Current Trends in Biomedical Engineering & Biosciences, 2017, vol. 9, issue 4, 68-76

Abstract: With the aid of Raman spectroscopy, the vibrational spectrum of molecules can be examined. Functional groups like amino, carboxyl or hydroxyl groups can be identified through characteristic vibrational frequencies. An automatic system is necessary in order to use RAMAN spectroscopy for high-throughput screening. We describe in this paper our novel method for automatic RAMAN spectra identification. The method is based on a featureless representation. The representation calculated based on delta modulation. Is a 0/1 sequences which can be used for comparison between different spectra’s. Three different similarity measures, the Hamming distance, the Levenshtein distance, and the Damerau-Levenshtein distance, have been studied. The pros and cons of these three distances are discussed in this paper. Finally, we present a novel and powerful method for spectrometer interpretation.

Keywords: juniper publishers group; juniper publishers Biomedical Engineering journals; Biomedical Engineering journals list; medical devices journals; peer reviewed Biomedical Engineering journals; open access Biomedical Engineering journals; Biomedical Engineering journals impact factor; Biomedical Engineering scientific journals; Biomedical Engineering articles; scholarly Biomedical Engineering journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/ctbeb/pdf/CTBEB.MS.ID.555768.pdf (application/pdf)
https://juniperpublishers.com/ctbeb/CTBEB.MS.ID.555768.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jctbeb:v:9:y:2017:i:4:p:68-76

DOI: 10.19080/CTBEB.2017.09.555768

Access Statistics for this article

Current Trends in Biomedical Engineering & Biosciences is currently edited by Sophia Mathis

More articles in Current Trends in Biomedical Engineering & Biosciences from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().