Hyper-Proliferation of Cell Action versus Apoptosis/Non-Apoptosis in Myc Amplification in Inducing Oncogenesis

Lawrence M Agius
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Lawrence M Agius: Department of Pathology, University of Malta Medical School, Europe

Cancer Therapy & Oncology International Journal, 2018, vol. 10, issue 4, 60-62

Abstract: The prevention of otherwise enhanced pro-apoptosis is signal targeting for the amplified MYC that induces powerful proliferation-prone dysjunction between contrasting apoptosis and non-apoptosis as evident especially in the context of metabolic over activity and switching to aerobic glycolysis of the Warburg phenomenon. It is the copy-number variability of amplified MYC that induces modulated non-apoptosis that paradoxically is enhanced within contexts of increased protein synthesis and of hyper-proliferation of cells. Additionally, there evolves the constitutive dimensions for transformation that opts for non-apoptosis of highly proliferative cells and of stem cells that are prevented to undergo terminal differentiation.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:10:y:2018:i:4:p:60-62

DOI: 10.19080/CTOIJ.2018.10.555793

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