A Truncated Form of the Polarity Protein SCRIB Induces Apoptosis in MDA-MB231 Cells by Regulating Components of Several Signalling Pathways

Maria Makkou, Joseph Papamathekis, Maria Makkou, Takis Makatounakis and Joseph Papamathekis
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Joseph Papamathekis: Department of Biology, University of Crete, Greece
Joseph Papamathekis: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas (FORTH), Greece

Cancer Therapy & Oncology International Journal, 2019, vol. 14, issue 4, 80-85

Abstract: Polarity proteins are fundamental to the establishment and maintenance of breast tissue integrity, whereas alterations of their amino acid sequence and protein structure can drive breast cancer formation and progression. Scrib is a multi-functional scaffold protein whose proper localization within the cell is pivotal for its correct function. We report here that the ectopic expression of a truncated form of the polarity protein Scrib, mainly composed of the LRR domain, drives MDA-MB231 breast cancer cells to caspase 3-mediated apoptotic cell death. Furthermore, we identify the truncated Scrib as a regulator of JNK/c-Jun, Notch and Wnt/β-catenin signalling pathways. Our results indicate that the ectopic expression of the truncated Scrib in a breast cancer cell line with a specific background of genetic mutations (KRAS, AFRGAP1, BRAF, MYCL) activates a program of intracellular molecular alterations and promotes apoptosis.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:14:y:2019:i:4:p:80-85

DOI: 10.19080/CTOIJ.2019.14.555894

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