T-Cell Large Granular Lymphocytic Chronic Leukemia: Treatment Experience with Cyclosporine

Ilie Alina, Guran Catalina, Oros Dacian Nicolae, Calamar Popovici Despina and Ionita Ioana
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Ilie Alina: Hematology Department, Emergency Municipal Hospital Timisoara, Romania
Ionita Ioana: Department of Internal Medicine 1 – Hematology, “Victor Babes†University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania

Cancer Therapy & Oncology International Journal, 2020, vol. 16, issue 4, 68-70

Abstract: The patient presented herself at the hospital in June 2018 with severe anemia (Hgb= 5,4g/dl), mild leucopenia (Le= 3980/mm³) and grade III neutropenia (Ne=557/mm³). She underwent bone marrow biopsy and flow cytometry which established the diagnosis of Large Granular T-cell Leukemia. She was given treatment with Ciclosporine 50mg 6cps/day, which was reduced at 3 cps/day because the patient developed pancytopenia at 6cps/day. The blood count test after 6 months of treatment was greatly improved: she obtained normal levels of hemoglobin and platelets, with the persistence of asymptomatic neutropenia. At the one-year follow-up we had an adequate response, but at the 18 months follow-up she has developed mild pancytopenia, which leads us to believe that she is relapsing under the Ciclosporine treatment.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:16:y:2020:i:4:p:68-70

DOI: 10.19080/CTOIJ.2020.16.555943

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