DNA Methylation: The Essential Link between Environmental Adversities and Major Depressive Disorder

Tridip Chatterjee and Ashim Kumar Basak

Global Journal of Intellectual & Developmental Disabilities, 2017, vol. 3, issue 5, 115-120

Abstract: Major depressive disorder has been a major public health problem. Multiple evidences suggests that epigenetic modification is essential in biological processes of depression. In recent times, DNA methylation has been regarded as a potential link between environment stress and depression. The genetic vulnerability is not able to explain by itself the development of major depression as it is a complex disorder where no single gene is sufficient to cause this disease. Probably each susceptibility gene contributes to a small fraction of the total genetic risk. In this present review an attempt has been made to elucidate the contribution of genetic and epigenetic factors and environment in the pathogenesis of major depressive disorder.

Keywords: Journal of Intellectual; Intellectual & Developmental; Intellectual & Developmental Disabilities; Journal of Intellectual & Developmental Disabilities; journal of intellectual disability research; journal of intellectual disabilities; journal of intellectual disability research impact factor; journal of intellectual property studies; open access publishers in usa; juniper publishers review (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjidd:v:3:y:2017:i:5:p:115-120

DOI: 10.19080/GJIDD.2017.03.555621

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