The Recombinant Vaccine against Human Chorionic Gonadotropin goes on Combined Immunogenicity, Safety and Efficacy Clinical Trials

Talwar Gp, Jagdish C Gupta, Kripa N Nand, Radhey S Sarma, Bandivdekar Ah, Rohini Sehgal, Indrani Ganguli and Alka Kriplani
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Kripa N Nand: Talwar Research Foundation, India
Radhey S Sarma: Indian Council of Medical Research, India
Bandivdekar Ah: National Institute for Research in Reproductive Health, India
Alka Kriplani: All India Institute of Medical Sciences, India

Global Journal of Reproductive Medicine, 2018, vol. 5, issue 1, 12-15

Abstract: A chemically synthesized vaccine inducing antibodies against human chorionic gonadotropin (hCG) was previously developed by Talwar et al. [1] which had undergone successfully Phase I and Phase II efficacy Clinical trials in sexually active women showing its ability to prevent pregnancy without derangement of ovulation,hormonal profiles and menstrual regularity (Table 1). It had high efficacy with only one pregnancy occurring in 1224 cycles. It was fully reversible and women desirous of having another child conceived readily on antibodies falling below 20ng/ml binding capacity [2]. The progeny born to previously immunized women had developmental land marks and cognitive abilities similar to their siblings [3].

Keywords: Journal of Reproductive Medicine; Reproductive Medicine; journal of reproductive medicine; reproductive medicine articles; reproductive medicine articles impact factor; reproductive medicine research journals; reproductive journals list; open access; juniper publishers journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjorm:v:5:y:2018:i:1:p:12-15

DOI: 10.19080/GJORM.2018.05.555654

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