Protective Effect of Purple Grape Juice on Homocysteine - Induced Oxidative Stress

Elif KaÄŸa, Ayhan Vurmaz and Ahmet Kahraman
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Ahmet Kahraman: Department of Biochemistry, Afyon Kocatepe University, Turkey

Global Journal of Pharmacy & Pharmaceutical Sciences, 2018, vol. 5, issue 2, 65-72

Abstract: The objective of this study was to evaluate the protective role of purple grape juice against oxidative damage induced by hyperhomocysteinemia in rats. For this purpose, rats were divided into 4 groups: Rats in the control group (n=8) received tap water with gavage and intraperitoneal (i.p.) saline solution (1ml/kg/day) for 30 days. Rats in the purple grape juice group (PGJ) (n=8) received purple grape juice (10ml/kg/day) with gavage and saline solution (1ml/kg/day). Rats in the homocysteine group (HCY) (n=8) received i.p. homocysteine (1ml/kg/day) and tap water (10ml/kg/day) with gavage. Rats in the purple grape juice+homocysteine group (PGJ+HCY) (n=8) received i.p. homocysteine (1ml/kg/day) and grape juice (10ml/kg/day) with gavage. During the study, plasma malondialdehyde (MDA), plasma carbonyl were assessed as indicators of oxidative stress; erythrocyte reduced glutathione (GSH), plasma sulfhydryl (SH) levels and erythrocyte catalase (CAT) and erythrocyte superoxide dismutase (SOD) activities were assessed as indicators of antioxidant capacity.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:5:y:2018:i:2:p:65-72

DOI: 10.19080/GJPPS.2018.05.555663

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