99mTc Labeled L-Tryptophan Conjugated Macrocyclic Chelating Agent: Synthesis, Characterization and In Vitro & In Vivo Biological Studies

Ranjeet Kumar, Bachcha Singh, Ankur Kaul and Anil K Mishra
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Bachcha Singh: Department of Chemistry, Banaras Hindu University, India
Anil K Mishra: Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2018, vol. 5, issue 3, 56-59

Abstract: Radiolabeled amino acids and their derivatives are an important class of imaging agents for PET and SPECT that target the increased levels of amino acid transport by many tumour cells. The novel amino acid (L-tryptophan methyl ester) based legend; 16Trp4A was successfully synthesized and well characterized through spectroscopic techniques and mass spectrometry which may be used as imaging agents. The pharmacokinetics of these compounds was analyzed by 99mTc labeled tracer methods. The labelling yield was found to be greater than 95%, as determined chromatographically by different solvent. Bio distribution studies in mice revealed significant uptake in blood, lung, liver, kidney, spleen and intestine initially, which decreases as time passes up to 24h. The maximum uptake of 99mTc -16Trp4A was found in liver 9.61+0.33, 5.95+0.29 and 3.66+0.19 %ID/g at 1,4 and 24h post injection, respectively, concluded that excretory pathway is hepatobiliary. Accumulation of activity in non-targeted organs and tissues (heart, brain, lungs, stomach, and intestine) was found

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:5:y:2018:i:3:p:56-59

DOI: 10.19080/GJPPS.2018.05.555661

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