A Clinical Review on Huntington Disease

Pooja Malkani, Prince Raj and Amit Singh
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Amit Singh: M. Pharm Research Scholar, Monad University, Uttar Pradesh

Global Journal of Pharmacy & Pharmaceutical Sciences, 2018, vol. 6, issue 4, 88-92

Abstract: Huntington disease (HD) is a progressive, fatal, neurodegenerative disorder caused by an expanded (Cytosine, Adenine, Guanine) CAG repeat in the huntingtin gene, which encodes an abnormally long polyglutamine repeat in huntingtin protein. HD is characterised by unwanted choreatic movements, behavioural and psychiatric disturbances and dementia. HD is an autosomal dominant inherited disease caused by an elongated CAG repeat (36 repeats or more) on the short arm of chromosome 4p16.3 in huntingtin gene. The longer the CAG repeat, and then the onset of disease is earlier.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:6:y:2018:i:4:p:88-92

DOI: 10.19080/GJPPS.2018.06.555693

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