Formulation and Optimization of Nanoparticale by 32 Factorial Design for Colon Targeting

Ganesh S Bangale, Shinde Gv and Rajesh Ks
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Ganesh S Bangale: Government College of Pharmacy, Amravati (M.S.), India
Shinde Gv: Parul Institute of Pharmacy, Baroda, India
Rajesh Ks: I.S.F. College of Pharmacy, Moga, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2019, vol. 7, issue 1, 8-22

Abstract: The aim of the present study was to develop stable nanoparticulate formulation for sustained release of Prednisolone. Chitosan nanoparticles were prepared by ionic gelation method using tripolyphosphate as cross-linking agent. Different nanoparticulate formulations were prepared by using 32 factorial design in which varying the concentration of chitosan (0.1% to 0.3%), concentration of tripolyphosphate (0.02% to 0.03%) as two factors. The effect of these factors on the particle size, % entrapment efficiency and in vitro drug release was evaluated to develop an optimized formulation.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:7:y:2019:i:1:p:8-22

DOI: 10.19080/GJPPS.2019.07.555702

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