Formulation Design for Poorly Water-Soluble Drug by Using Solid Dispersion of Telmisartan for Solubility and Dissolution Rate Enhancement

A Deevan Paul, Jada Vinay, K G Rajyalakshmi and P V Prasad
Additional contact information
P V Prasad: Academic Consultant, SV University, India

Global Journal of Pharmacy & Pharmaceutical Sciences, 2019, vol. 7, issue 4, 94-104

Abstract: Formulating the drug into solid dispersion (SD) by fusion method and solvent evaporation method using different grades of PEG in comparison to plain telmisartan drug with optimised solid dispersion tablets. The Preformulation studies like FTIR and DSC studies for drug excipient compatibility stated that the drug and carrier selected for the study and are compatible for further studies. SD was prepared by using the drug Telmisartan by two methods, fusion method and solvent evaporation method, eighteen formulations were prepared and characterized in terms of various parameters. The in vitro drug for all the formulations were in the range of 82.38%-95.73% for fusion method and 91.45% to 96.81% for solvent evaporation method and tablets it ranges from 95.70% to 99.40%. The in-vitro release studies have shown that the cumulative drug release values were within the range of 14.23%-94.54% for fusion method, 18.57%- 95.89% for solvent evaporation method and 14.35% - 99.53% for tablets. The fast drug release about 99.53% was found in the F22 formulation by solvent evaporation method in solid dispersion tablets in the ratio of 1:2 and drug content was found to be 99.53% and disintegration time was 1.09 seconds and all parameters were found to be greater than all other formulations.

Keywords: juniper publishers:Journal of Pharmacy; Global Journal of Pharmacy; Pharmaceutical Sciences; Pharmacy & Pharmaceutical Sciences; pharmaceutical sciences journals; omics online; open access; drug discovery; Clinical Trials; juniper publishers open access journals; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/gjpps/pdf/GJPPS.MS.ID.555716.pdf (application/pdf)
https://juniperpublishers.com/gjpps/GJPPS.MS.ID.555716.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jgjpps:v:7:y:2019:i:4:p:94-104

DOI: 10.19080/GJPPS.2019.07.555716

Access Statistics for this article

Global Journal of Pharmacy & Pharmaceutical Sciences is currently edited by Sophia Mathis

More articles in Global Journal of Pharmacy & Pharmaceutical Sciences from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().