Tyrosine on Cutaneous Pigmentation - A New Therapy Line for Vitiligo

Aruna V, Soundharya R, Amruthavalli Gv and Gayathri R
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Gayathri R: Dr. JRK’s Research and Pharmaceuticals Pvt. Ltd, India

JOJ Dermatology & Cosmetics, 2020, vol. 3, issue 3, 55-62

Abstract: The topical effect of tyrosine in altering skin pigmentogenesis was studied using melanin pigment producing strain of Cryptococcus neoformans. Although the biochemical pathway is different in C. neoformans, where phenol oxidase enzyme is involved unlike tyrosinase as in the case of mammalian cell, still the findings prove the method to be reliable and reproducible. Peri-cellular absorption of tyrosine and subsequent melanogenesis were observed in treated cell of C neoformans. Further the quality of pigment produced in the cell of the organism was different from phenol oxidase induced pigment. The pigment thus offered protection to the cells from UV damage. The observation based study on tyrosine based cream in human skin and subsequent sun exposure resulted in minimal erythema and delayed pigment darkening indicating the underlying melanogenesis process. Further, the absence of erythema suggests the possible melanogenesis activation at sub-dermal level and its effect in protecting the skin from sun damage. The clinical usefulness of topical tyrosine and other scientific details are discussed in the paper.

Keywords: Open Access Journal of Dermatology & Cosmetics; juniper publishers dermatology Journals; dermatology journal impact factor ranking; dermatology online journal impact factor; dermatology online journal psoriasis; dermatology online journal author; scholarly open access journals; peer reivewed journals; junipe publishers review (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jjojdc:v:3:y:2020:i:3:p:55-62

DOI: 10.19080/JOJDC.2020.03.555614

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