PPARα as Potential Therapeutic Target for Neurodegenerative Diseases

Letizia Giampietro and Rosa Amoroso
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Rosa Amoroso: Department of Pharmacy, university G.d’ Annunzio, Italy

Novel Approaches in Drug Designing & Development, 2017, vol. 2, issue 5, 98-101

Abstract: Peroxisome proliferator activated receptor α (PPARα) is ligand-activated transcriptional factor receptor belonging to nuclear receptors family. It plays a key role in lipid metabolism and glucose homeostasis and it is important in the prevention and treatment of metabolic diseases. PPARα has also a protective effects against brain cell death attributed to its anti-inflammatory and antioxidant properties. In the present work, we discuss the PPAR involvement in neurodegenerative pathologies and its potential as therapeutic target for these diseases.

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Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:2:y:2017:i:5:p:98-101

DOI: 10.19080/NAPDD.2017.02.555599

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