Influence of Glutamate Receptor Antagonist Mk801 on Human Sperm Movement and Impregnating Ability

Zhang Jinfu, Zhang Wenping, Qi Lixin, Le Wei, Hu Jiahua, Guo Lihe and Feng Huailiang
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Zhang Jinfu: Department of Urology, Shanghai Tongren Hospital, China
Zhang Wenping: Department of Dermatology, Tongji Hospital of Tongji University School of Medicine, China
Le Wei: Department of Urology, Tongji Hospital of Tongji University School of Medicine, China
Guo Lihe: Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, China
Feng Huailiang: Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, USA

Novel Approaches in Drug Designing & Development, 2017, vol. 3, issue 2, 28-31

Abstract: N-methyl-D-aspartate (NMDA) receptor subunit 2B (NR2B) was found to be expressed in human sperm in our previous study. Here, we extended this observation to evaluate the potential pharmacological actions of NR2b-targeting reagents on sperm by using a sperm-activity assay and a sperm-cervical mucus-contact test. It was shown that MK-801 [(+)-5-methyl-10, 11-dihydroxy-5H-dibenzo(a, d) cyclohepten-5, 10-imine], a well-known potent NR2B antagonist, markedly interfered with the direction and speed of sperm movement as well as apparently inhibited the ability of sperm to pass through uterus mucilage. Thus, MK-801 acts by inhibitions of sperm motility and fertilization, which are possibly via NR2B antagonism. The present findings indicate that NR2B-targeting compounds such as MK-801 have the potential to be used clinically for decreasing the probability of human pregnancy and would meet the contraceptive need of people.

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Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:3:y:2017:i:2:p:28-31

DOI: 10.19080/NAPDD.2017.03.555607

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