Relation between Minimum Inhibitory Concentration and Chemical Structure of Heterocyclic Organic Compounds against Mycobacterium

Vida Sedighi, Masoomeh Shirzad, Safora Hariri, Pegah Adelvand and Soroush Sardari
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Soroush Sardari: Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Iran

Novel Approaches in Drug Designing & Development, 2018, vol. 4, issue 2, 38-46

Abstract: This study aimed to study different derivatives of heterocyclic organic compounds and related antibacterial activities of these compounds which were evaluated against Mycobacterium tuberculosis. This review represents an overview of minimum inhibitory concentration (MIC) of these compounds to find a meaningful relationship between chemical structure of the compounds and the related MIC values. The chemical structures of these compounds have been classified into 11 groups. Among the 100 evaluated compounds in this study, a non-fused heterocyclic compound and fused heterocyclic compound were found to be the most active compound with MIC of 0.06 and 0.003 μg/ml against Mycobacterium, respectively. Some chemical properties impact antibacterial activities of these compounds, which depend on the delocalized electrons in the structure of the compounds and the presence of electronegative element such as nitrogen or oxygen in the rings of the compounds.

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Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:4:y:2018:i:2:p:38-46

DOI: 10.19080/NAPDD.2018.04.555633

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