Smart Bio-Polymer From Tapioca Sago Possessing Novel In-Built Filmability By Synergistic Approach Using Film Initiator

Kirti Singh and Satheesh Madhav Nv
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Satheesh Madhav Nv: Faculty of pharmacy, Novel Drug Delivery Research Lab, DIT University, India

Novel Approaches in Drug Designing & Development, 2018, vol. 4, issue 2, 54-57

Abstract: The main objective of this research work was to isolate a bio-polymer from Tapioca sago and formulate bio-flexy films. A novel bio-polymer was isolated from a natural and edible source Tapioca sago and using the bio-polymer five bio-flexy films of different ratios (i.e. 1:1, 1:2, 1:3, 1:4, 1:5) were formulated using a model drug i.e; Atorvastatin and other co-processing agents. The isolated bio-polymer was subjected to various analytical parameters. The drug-excipient compatibility study was performed using UV and TLC method. The formulated bio-flexy films were evaluated for various parameters like weight, thickness, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation AT4 (containing 1:4 bio-polymer) was found to be the best formulation having R2 value 0.995 with zero order as best fit model. The results obtained concluded that bio-polymer isolated from Tapioca sago can be used as a film forming agent and further can be utilized in various formulations.

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Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:4:y:2018:i:2:p:54-57

DOI: 10.19080/NAPDD.2018.04.555635

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