A New Look at the Malignant Growth in Regenerating Animal Tissue and Cells

Karel Sláma
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Karel Sláma: Laboratory of Insect Physiology, Czech Republic, Europe

Novel Approaches in Drug Designing & Development, 2019, vol. 5, issue 1, 11-18

Abstract: Regeneration of the naturally dead or artificially removed insect epidermal cells is executed by induction of mitotic divisions at the margin of the wound. The regenerated cells unite with the old epithelium and restore the tissue integrity, which gives a signal for arresting further mitotic divisions. It was found that proliferaton of insect epidermal cells required the presence of polyhydroxylated derivatives of 6-keto, 7-dehydrochoolesterol (ecdysone, ecdysteroids, Ecd). These compounds were accidentally discovered in the search for insect moulting hormone. Extensive investigations revealed, however, that Ecd were not animal hormones. According toi their wide distribution in plants and strong anabolic, growth promoting effects in domestic animals and humans, the biological status of Ecd has been identified as the previously neglected and incorrectly identified vitamin D1.

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Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jnapdd:v:5:y:2019:i:1:p:11-18

DOI: 10.19080/NAPDD.2019.05.555654

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