Intracranial Meningeal Carcinomatosis from Prostate Cancer

Thalmann Sandrine, Kuhn Peter, Allal Abdelkarim S, Küng Marc, Molteni Thierry and Thoeny Harriet C
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Allal Abdelkarim S: Department of Radiation Oncology, HFR Fribourg, Switzerland
Küng Marc: Department of Medical Oncology, HFR Fribourg, Switzerland
Thoeny Harriet C: Department of Radiology HFR Fribourg, Switzerland

Open Access Journal of Neurology & Neurosurgery, 2019, vol. 10, issue 4, 73-75

Abstract: Due to an apparent increase in the number of cases of intracranial meningeal carcinomatosis in patients with prostate cancer observed in the early 2010s, we undertook a retrospective study to explore possible associated factors. Between 2008 and 2014 we identified 10 patients presenting with meningeal carcinomatosis. The time between the initial diagnosis, the first metastasis, the first chemotherapy, and the diagnosis of meningeal carcinomatosis were analyzed as well as the possible factors associated with this peculiar tumor spreading. The median time from the initial diagnosis to the development of meningeal carcinomatosis was 54 months. There were 21 months between the first chemotherapy and the diagnosis of meningeal carcinomatosis. Docetaxel was given in 80% of the patients. Along with the younger age of the patients (median 56 years) docetaxel appears to be the main common factor that characterized this cohort of patients. Several hypotheses that may explain this temporary increase of this metastasizing mode are elaborated and discussed in the present article.

Keywords: Open Access Journal of Neurology; Journal of Neurology & Neurosurgery; Open Access Journal; juniper publishers; neurology open access journals; journal of neurology; neurology indexed journals; neurology scholarly journals; journal of neurology; neurology journals impact factor; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joajnn:v:10:y:2019:i:4:p:73-75

DOI: 10.19080/OAJNN.2019.10.555793

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