Alzheimer’s Disease: An Overview

Shivangi Sharma, Aaliya Bari, Javed Akhtar, Meenu Yadav, Rajendra Nath and Rishi Pal
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Rishi Pal: Department of Pharmacology & Therapeutics, King George’s Medical University, India

Open Access Journal of Neurology & Neurosurgery, 2019, vol. 11, issue 4, 79-84

Abstract: Alzheimer’s disease presently is a huge burden on society and the situation is only going to worsen in coming years. Today more than 25 million people in the world are affected by dementia and more than 75% of all dementia cases are due to Alzheimer’s Disease (AD) and this number is bound to increase in coming years. AD is a neurodegenerative disorder where the loss of hippocampal and cortical neurons leads to impairment of memory and cognitive ability. The main neurochemical disturbance in AD is a deficiency of ACh. In AD there is protein accumulation as neuritic plaques containing amyloid beta protein (Aβ), NeuroFibrillary Tangles (NFTs) composed of hyperphosphorylated tau filaments which induce neuronal dysfunction and death by various mechanisms currently under study like-direct impairment of synaptic transmission and plasticity (AMPA receptors), excitotoxicity, oxidative stress, and neuroinflammation.

Keywords: Open Access Journal of Neurology; Journal of Neurology & Neurosurgery; Open Access Journal; juniper publishers; neurology open access journals; journal of neurology; neurology indexed journals; neurology scholarly journals; journal of neurology; neurology journals impact factor; juniper publishers reivew (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joajnn:v:11:y:2019:i:4:p:79-84

DOI: 10.19080/OAJNN.2019.11.555816

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