Anti-Microbial Properties of C-benzylated Dihydro Chalcone Derivatives: 2’, 4’-Dihydroxy-3’,5’-( 2’’, 2’’’- Dihydroxy Dibenzyl) - 6’-Methoxy Dihydro Chalcone, 2’,4’-Dihydroxy-3’- ( 2’’- Hydroxy Benzyl) –6’- Methyl Dihydrochalcone and 2’, 4’, 6’ – Tri Hydroxy- 3’- ( 2’’-Hydroxy Benzyl) Dihydro Chalcone Isolated from Stem Bark of Uvaria Chamae P. Beav

Ado K, Salihu L, Garba S, Nwaedozie Jm and Aliyu Ab
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Nwaedozie Jm: Department of Chemistry, Nigerian Defence Academy, Kaduna
Aliyu Ab: Department of Chemistry, Ahmadu Bello University, Zaria

Organic & Medicinal Chemistry International Journal, 2020, vol. 10, issue 1, 4-13

Abstract: Two new C- benzylated dihydro chalcones derivatives:, 2’, 4’- dihydroxy- 3’ – (2†, - hydroxyl benzyl)- 6’ –methyl dihydro chalcone , 2’, 4’, 6’- trihydroxy-3’- (2’’ – hydroxy benzyl) dihydro chalcones and a known compound, 2’, 4’- dihydroxy-3’, 5’ – (2’’. 2†’ –dihydroxy benzyl) – 6’- methoxy dihydro chalcone (diuvaretin) were isolated from the stem-bark of Uvaria chamae. The structures of the compounds were elucidated by spectroscopic methods: FTIR, 1HNMR, 13CNMR as well as by comparison with literature data. The isolated compounds were evaluated for their antibacterial and antifungal activities using Disc diffusion method. All the three compounds exhibited high activities against all the tested microbes with diuvaretin exhibiting the highest activities with inhibition zones ranging from 12-30 mm, for bacterial and 14-30mm for fungal organisms, at the highest concentration of 1000μg/cm3. Therefore, U. chamae contain promising antimicrobial compounds with diverse biological activities that can be used in developing drugs for curing life threatening diseases caused by the tested organisms such as typhoid fever, darriahoea and aflotoxins caused by molds.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:10:y:2020:i:1:p:4-13

DOI: 10.19080/OMCIJ.2020.10.555778

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