Discovery of Original Tricyclic Imidazopyridines during a Search for Nurr1 Nuclear Receptor Agonists

Aline Moulin, Jean François Peyronel, Benoit de Carne Carnavalet and Dominique Lesuisse
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Jean François Peyronel: Skyepharma Production SAS, France
Dominique Lesuisse: Rare and Neurologic Diseases, Sanofi, France

Organic & Medicinal Chemistry International Journal, 2021, vol. 10, issue 3, 105-112

Abstract: This paper describes the exploration of original tricyclic analogues of compound 1, previously identified as a lead compound during a Programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson’s disease. We discovered several tricyclic [5,6,5]-imidazo[1,2-a]pyridines along with efficient ways of preparing them. These new heterocycles are novel starting points for original chemical series.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:10:y:2021:i:3:p:105-112

DOI: 10.19080/OMCIJ.2021.10.555790

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