Chemical and Biological Potentials of Chalcones A Review

Shaik Khadar Yazdan, D Vidya Sagar and Afzal Basha Shaik
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Shaik Khadar Yazdan: Department of Pharmacy, Victoria College of Pharmacy, India
D Vidya Sagar: Department of Pharmacy, Veerayatan Institute of Pharmacy, India
Afzal Basha Shaik: Department of Pharmacy, Vignan Pharmacy College, India

Organic & Medicinal Chemistry International Journal, 2015, vol. 1, issue 1, 20-28

Abstract: Plants from the natural world are linked with the treatment of different human ailments. This is due to the presence of different classes of chemical constituents. Flavonoids are one such class of natural constituents responsible for the activity of plants. Chalcones are a class of natural open chain flavonoids that are linked by a three carbon spacer between two aromatic rings. Chalcones and their heterocyclic analogues enjoy a range of biological activities such as antimicrobial, antioxidant, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and anti-inflammatory activities which makes these compounds as a special attraction for investigation. Additionally the bielectrophilic, ketovinyl chain between the two rings is highly reactive and acts as an important chemical synthon for constructing different five, six and seven membered heterocyclic scaffolds containing different hetero atoms like nitrogen, oxygen and sulfur atoms by abridgment with a variety of binucleophilic reagents. This review highlights on the chemical and biological potentials of chalcones.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2015:i:1:p:20-28

DOI: 10.19080/OMCIJ.2015.01.555553

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