Dihydroquinazolinones as Potential Antiproliferative and Tumor Inhibiting agents

Kereyagalahally H Narasimhamurthy, Hanumappa Ananda, Kothanahally S SharathKumar and Kanchugarakoppal S Rangappa
Additional contact information
Kanchugarakoppal S Rangappa: Department of Studies in Chemistry, Manasagangotri, University of Mysore, India

Organic & Medicinal Chemistry International Journal, 2016, vol. 1, issue 2, 64-69

Abstract: 2,3dihydroquinazolinone derivatives were screened for their antiproliferative activity, among all the synthesized molecules compound 3j with electron withdrawing substituents on phenyl ring displayed considerable cytotoxicity against HeLa, MCF7 and K562 cell lines with an IC50 value of 17.1, 31.5 and 25.3 μM, respectively. Further we carried out live dead fluorescence dye assay using calcein-AM and ethidium homodimer staining results further validate the capacity of compound 3j it induces apoptosis in HeLa cells. In addition, the potent compound 3j tested for tumor regression studies in Swiss albino mouse. Both in vitro and in vivo results revealed the significant antiproliferative activity of compound 3j in tumor cell lines and tumor tissue showed multifocal areas of necrosis and numerous number of apoptotic cells.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555560.pdf (application/pdf)
https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555560.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2016:i:2:p:64-69

DOI: 10.19080/OMCIJ.2016.01.555560

Access Statistics for this article

Organic & Medicinal Chemistry International Journal is currently edited by Sophia Mathis

More articles in Organic & Medicinal Chemistry International Journal from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().