Petra, Osiris and Molinspiration: A Computational Bioinformatic Platform for Experimental in vitro Antibacterial Activity of Annulated Uracil Derivatives

Ajmal R Bhat, Rajendra S Dongre and Pervaz A Ganie
Additional contact information
Rajendra S Dongre: Department of Chemistry, S.B.B.S.University, Jalandhar Punjab-144030, India
Pervaz A Ganie: Department of chemistry, R.T.M., Nagpur University, Campus, Nagpur 440033, India.

Organic & Medicinal Chemistry International Journal, 2017, vol. 1, issue 3, 103-110

Abstract: Annulated pyrano [2,3-d]pyrimidine/pyrano[2,3-d]uracil derivatives were synthesized using aromatic aldehydes, active methylene compounds and barbituric acid in presence of dibutylamine (DBA) catalyst in ethanol as solvent. The different substituents on phenyl ring in the fused pyrano uracil skeleton showed productive influence on its antimicrobial activity against some gram positive and gram negative bacteria like Pseudomonas aureus, E. coli, Staphylococcus aureus, Klebsiella pneumonia and Bacillus cereus. Antibacterial screening revealed that the presence of heteroaryl, cyano and amino groups on uracil skeleton increases its penetrating power on bacterial cell wall and product becomes more biologically energetic. The antimicrobial activity results showed some definite and interesting facts about the structure activity relationship (SAR) of synthesized molecules.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://juniperpublishers.com/omcij/pdf/OMCIJ.MS.ID.555565.pdf (application/pdf)
https://juniperpublishers.com/omcij/OMCIJ.MS.ID.555565.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2017:i:3:p:103-110

DOI: 10.19080/OMCIJ.2017.01.555565

Access Statistics for this article

Organic & Medicinal Chemistry International Journal is currently edited by Sophia Mathis

More articles in Organic & Medicinal Chemistry International Journal from Juniper Publishers Inc.
Bibliographic data for series maintained by Robert Thomas ().