In vitro Evaluation of Antifungal Activity of Callicarpa macrophylla Vahl. Leaves

Tripathi Yc, Nishat Anjum and Lokesh Upadhyay
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Nishat Anjum: Chemistry Division, Forest Research Institute, Dehradun, India
Lokesh Upadhyay: Centre for Interdisciplinary Biomedical Research, Adesh University, Bathinda, Punjab, India

Organic & Medicinal Chemistry International Journal, 2017, vol. 1, issue 4, 168-171

Abstract: Aqueous extracts of leaves of Callicarpa macrophylla Vahl. traditionally known for medicinal value were evaluated for antifungal efficacy against six pathogenic fungi namely viz, Alternaria alternata, Aspergillus flavus, Aspergillus niger, Cladosporium cladosporidies , Drechslera halodes and Fusarium moniliforme by agar-well diffusion method. The minimum inhibitory concentration (MIC) was determined through the broth dilution method which was found in the range of 3.50 – 4.25 mg/ml. Aqueous extract of C. macrophylla leaves exhibited varying degrees of antifungal activity against all the six test fungi. Radial growth inhibition of at concentration of 5, 10, 20 and 30 mg/ml was much less than that of positive control. However, 40 and 50 mg/ml test concentration of extract was considerably effective on growth inhibition of all the test fungi. The study thus revealed the promising antifungal efficacy of C. macrophylla leaves and its potential for development of botanical fungicide.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2017:i:4:p:168-171

DOI: 10.19080/OMCIJ.2017.01.555571

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