Synthesis, Drug Likeness and Antioxidant Activity of Analogues of L-Arginine

AinaOlayinka, Afolabi Ezekiel, Odumosu Patricia and Ojerinde Stephen
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Ojerinde Stephen: Department of Pharmaceutical chemistry, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria

Organic & Medicinal Chemistry International Journal, 2017, vol. 1, issue 5, 186-189

Abstract: Free radicals damage is responsible for the development many chronic health problems. 3 analogues of L-arginine were synthesized and their structures were confirmed with FTIR, 1H and 13C NMR. Molecular properties and bioactivity prediction of the synthesized compounds was carried out with molinspirationsoftware. The antioxidant activity of the synthesized compounds was evaluated in vitro using DPPH radical scavenging assay. The compounds obeyed Lipinsky rule of five and showed good bioactivity scores. The analogues A1-A3 exhibited low antiradical activity against with IC50 value of 631.06, 501.19 and 537.02μg/ml respectively

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:1:y:2017:i:5:p:186-189

DOI: 10.19080/OMCIJ.2017.01.555574

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