Synthesis, Characterization and Biological Evaluation of Copper (ii) Metal Complex with 1,10-Phenanthroline

Akbar Ali Thebo, Noor Ahmad Nahyoon, Shah Nawaz Phulpoto, Azim Khan, Sohail Ahmad Shah, Sajjad Ali and Khalid H Thebo
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Akbar Ali Thebo: National Center for Nanoscience and Technology (NCNST), Chinese Academy of Sciences (CAS), China
Noor Ahmad Nahyoon: School of Environmental Science & Technology, Dalian University of Technology, China
Shah Nawaz Phulpoto: College of Material Science & Engineering, Beijing University of Chemical Technology, China
Khalid H Thebo: Institute of Metal Research, Chinese Academy of Science, China

Organic & Medicinal Chemistry International Journal, 2017, vol. 2, issue 1, 8-12

Abstract: Novel copper(II) complex, [Cu(phen)2(OH2)(NO3)2] (1) (where phen = 1,10-phenanthroline) have been synthesized and characterized by elemental analysis, FTIR, EPR, thermo gravimetric analysis, X-ray crystallography and biological activity. Crystal structure determination reveals that complexes (1) possess a neutral monomeric structure. In complex (1), five atoms (N and O) are coordinated with copper (II) ion to form distorted square pyramid structure. Amongst five coordinating atoms, four are nitrogen atoms from two 1,10-phenanthroline moities and one oxygen atom. The thermal decomposition of the complex (1) under an inert atmosphere has also been studied. Furthermore the complex (1) was screened for their anti-microbial activity, and antifungal cytotoxicity. Antibacterial and antifungal results indicate that the metal complexes are more active than the ligand.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:2:y:2017:i:1:p:8-12

DOI: 10.19080/OMCIJ.2017.02.555578

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