Topical Salicylic acid and Lactic acid Microemulsion

Maher Aljamal, Ibrahim Kayali and Mohammad Abul-Haj
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Ibrahim Kayali: BeitJala Pharmaceutical Company / Research and Development department, Palestine
Mohammad Abul-Haj: Department of Chemistry, Palestine, Al- Quds university, Israel

Organic & Medicinal Chemistry International Journal, 2017, vol. 2, issue 3, 49-54

Abstract: Microemulsionsare used to solubilizing and improve an active pharmaceutical ingredientssolubility and permeability, such as those for topical absorption availability. The objective of this study was to prepare a microemulsion liquid composed of 12% salicylic acid and 4% of lactic acid using castor oil, Tween 80, propylene glycol, ethyl alcohol and purified water. Using the low energy emulsification technique; four pseudo ternary phase diagrams were constructed and studied for at least 75 days under a titration method using purified water (with or without propylene glycol), each phase diagram was investigated at 25°C, 37°C and 45°C. The phases include conventional emulsion, viscous and transparent/translucent microemulsion. The Results indicate a clear, thermodynamic microemulsion liquid obtained in each of the constructed phase diagrams at all temperatures of study. Using propylene glycol as a co-surfactant, lead to more stable microemulsionsby using low concentration of Tween 80. It was suggested that microemulsions of 12% Salicylic acid and 4% Lactic acid could be a suitable vehicle for topical treatment of psoriasis, scaly patches, ichthyoses, dandruff, corns, calluses, and wartson the hands or feet. This study may be useful in formulating a delivery system for the pharmaceutical industry as well as in cosmetics and personal care products.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:2:y:2017:i:3:p:49-54

DOI: 10.19080/OMCIJ.2017.02.555587

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