Chemistry and Biological Potential of Pyrimidine Derivatives: Study of Nucleosides with Pyrimidines

Mohammad Asif
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Mohammad Asif: Department of pharmacy, GRD (PG) Institute of Management and Technology, India

Organic & Medicinal Chemistry International Journal, 2017, vol. 2, issue 5, 113-124

Abstract: Much attention has been devoted to the preparation of nucleosides with pyrimidinic bases and their derivatives, especially uracils. Uracils are an important heterocycles because of their applications as bioactive compounds like 5-iodouridine, 2(S)-will-ardiine, zidovudine and tifluridine. This scaffold is of prime importance to chemists and biologists to yield diverse type of new molecules and screen these new entities for pharmacological activities. These synthesized molecules exhibited a variety of activities like antitumor, tuberculostatic, anti-diarrhea], anticonvulsants, antibacterial, antimicrobial, tyrosine kinase inhibitor, calcium channel antagonists, antileishmanial, diuretic, anti-inflammatory and analgesic etc. These observed activities systematic molecular manipulations have yielded several types of clinically used drugs like anti-cancer drug, nucleoside based anti-AIDs drugs, CNS acting drugs.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:2:y:2017:i:5:p:113-124

DOI: 10.19080/OMCIJ.2017.02.555598

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