Electrophilic Fluorination with 1-Fluoro-2,4,6-trimethylpyridinium tetrafluoroborate and NFSI (N-Fluorobenzenesulfonimide) reagents directed towards the synthesis of heterocycles Current Trends

Pankaj Sharma, Nutan Sharma, Amit Kumar and SunitaBhagat
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SunitaBhagat: Department of Chemistry, ARSD College, University of Delhi, India

Organic & Medicinal Chemistry International Journal, 2017, vol. 3, issue 4, 109-119

Abstract: The phytochemical screening and the antidiarrhoeal activities of the crude extracts from the leaves Landolphiaowariensis were carried out using standard methods. The results of the phytochemical screening showed that the plant contained alkaloids, saponins, tannins, flavonoids and glycosides. The results of the antidiarrhoeal screening of the crude extracts showed that Landolphiaowariensis exhibited zone of inhibition ranging from 15 mm to 35 mm against test microbes. Ethyl-acetate extract of the Landolphiawariensis being the most active fraction was subjected to column chromatography, leading to the isolation of single compound that showed a high activities (zone of inhibition from 8mm to 32mm) against these causative agents of diarrhoea (Salmonella Typhi, Shigelladysentriaeand Escherichaia Colirespectively). Spectroscopic analysis of the isolated compound using 1HNMR, 13CNMR, IR and GCMS showed that the compound was Cis-9-Octadecenoic acid. The result of this works therefore showed that the extract from the leaves of Landolphiaowariensis could be used for the treatment of diarrhoea and other diseases caused by targeted microorganisms.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:3:y:2017:i:4:p:109-119

DOI: 10.19080/OMCIJ.2017.03.555620

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