Multi Component Green Synthesis of Bis-Pyrrol Indoline-2-Ones Triazoles Catalysed By Cu NPS on Activated Carbon in Water

B Saritha, P Venkata Ramana, D Madhavi and Ravindranath Lk
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Ravindranath Lk: Department of Chemistry, Sri Krishnadevaraya University, India

Organic & Medicinal Chemistry International Journal, 2017, vol. 4, issue 1, 14-21

Abstract: A variety of potentially biological active multi component green synthesis of Bis-pyrrol indoline-2-ones triazoles possessing N- alkyl furan/ N- alkyl thiophene /N- alkyl pyrrol by catalysed Cu-NPs on activated carbon in water involving green synthetic technology have been developed. It involves in three steps. The first step involves the synthesis of 1-prop-2-ynyl indoline-2,3-dione(3) from indoline -2,3-dione and 3-chloropropanone(2). The intermediate1-prop-2-ynyl indoline-2,3-dione(3) was converted into 1-((1-furan/thiophene/pyrrol/phenyl/4-methyl phenyl/4-fluoro phenyl/4- trifluro methyl phenyl/4-nitro phenyl)-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)indiline-2,3-dione (5a-h) by 1,3-dipolar cyclo addition with 2-bromo methyl-1H-furan/ 2-bromo methyl-1H-thiophene/ 2-bromo methyl-1H-pyrrol benzyl bromide/4-methyl benzyl bromide/4-fluoro benzyl bromide/4-tri fluoro benzyl bromide/4- nitro benzyl bromide (4a-h) catalysed by Cu-NPs on activated carbon catalysed click reaction in neat water depicted in step-2.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:4:y:2017:i:1:p:14-21

DOI: 10.19080/OMCIJ.2017.04.555630

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