Facile Synthesis of Some Novel 1, 3, 4-Oxa diazole Derivatives Associated with Pyrimidine Core Unit as a Anti-Microbial Agents

Virupakshi Prabhakar, Sreenivasulu Peta and Srinivasula Reddy Maddula
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Virupakshi Prabhakar: Faculty of Chemistry, Rajiv Gandhi University of knowledge technologies, India
Srinivasula Reddy Maddula: Prajna Generics Private Limited, India

Organic & Medicinal Chemistry International Journal, 2017, vol. 4, issue 2, 31-36

Abstract: A new series of 2-(4-phenylpyrimidin-2-yl)-5-p-substituted-1, 3, 4-oxadiazole derivatives (8a-j) were synthesized after refluxing 4-phenylpyrimidine-2-carbohydrazide[6] with different aromatic/Heterocyclic carboxylic acids (7 a-j) in the presence of POCl3. The chemical structures of these compounds were confirmed by various physico-chemical methods viz. IR, [1] H-NMR, EI-Mass, [13] C-NMR analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram-positive and gram-negative bacterial strains and fungi strains. The compounds 8j, 8i and 8h shows highly significant antimicrobial activity as compared to the standard drug.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:4:y:2017:i:2:p:31-36

DOI: 10.19080/OMCIJ.2017.04.555634

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