The Furan Approach to the Synthesis of the (+)-Civet Constituent (+)-2-((2S,6S)-6-Methyltetrahydro-2H-Pyran-2-yl) Acetic Acid

Isela García, Fátima Garrido, Generosa Gómez, Yagamare Fall, Alioune Fall and Mohamed Gaye
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Yagamare Fall: Departamento de Química Orgánica, Facultad de Química and Instituto de Investigación Sanitaria Galicia Sur (IISGS), University of Vigo, Spain
Mohamed Gaye: Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques: Université Cheikh Anta Diop de Dakar, Sénégal, Africa

Organic & Medicinal Chemistry International Journal, 2017, vol. 4, issue 4, 66-68

Abstract: We describe an efficient new approach for the synthesis of the civet constituent (2S,6S)-(6-Methyltetrahydropyran-2-yl) acetic acid from commercially available starting material using the furan approach, a methodology we developed some years ago, which is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular hetero Michael addition.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:4:y:2017:i:4:p:66-68

DOI: 10.19080/OMCIJ.2017.04.555641

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