Synthesis, Characterization & Biological Evaluation of Mutual Prodrugs of Some Selected NSAIDs conjugated with different antioxidant via different amino acids

Sharma N
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Sharma N: K N Modi Institute of Pharmaceutical Educational & Research, India

Organic & Medicinal Chemistry International Journal, 2017, vol. 4, issue 4, 69-73

Abstract: Some selected non-steroidal anti-inflammatory drugs (Aceclofenac, Diclofenac), have been conjugated with antioxidant (Guaiacol, Menthol) via Amino acid spacer (Phenylalanine, Glycine) which has anti-inflammatory, cytoprotective and immunomodulatory properties; therefore this conjugation will synergize the effect of the parent NSAIDs as anti-inflammatory drugs and reducing their gastric side effects. Four compounds have been synthesized andthe structure was confirmed by using IR, NMR (1H-NMR) & Characterized by some physicochemical properties including Melting point. IR data were recorded on Shimadzu FT-IR Spectrophotometer using KBr pellets method & 1H-NMR spectra in DMSO on Bruckerspectrospin-300 MHz using TMS as internal standard. The purity of the synthesized compounds was checked by its TLC. Developing solvents used for the process was [Methanol: Chloroform (2.5ml: 7.5ml)]. TLC plates were made by using Silica gel G & Silica gel GF.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:4:y:2017:i:4:p:69-73

DOI: 10.19080/OMCIJ.2017.04.555642

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